Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1.

doi:10.1038/ng.934

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Article

Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1.

Nature genetics - 11 Sept 2011

LeMaire Scott A, McDonald Merry-Lynn N, Guo Dong-Chuan, Russell Ludivine, Miller Charles C, Johnson Ralph J, Bekheirnia Mir Reza, Franco Luis M, Nguyen Mary, Pyeritz Reed E, Bavaria Joseph E, Devereux Richard, Maslen Cheryl, Holmes Kathryn W, Eagle Kim, Body Simon C, Seidman Christine, Seidman J G, Isselbacher Eric M, Bray Molly, Coselli Joseph S, Estrera Anthony L, Safi Hazim J, Belmont John W, Leal Suzanne M, Milewicz Dianna M

Abstract excerpt

Although thoracic aortic aneurysms and dissections (TAAD) can be inherited as a single-gene disorder, the genetic predisposition in the majority of affected people is poorly understood. In a multistage genome-wide association study (GWAS), we compared 765 individuals who had sporadic TAAD (STAAD) with 874 controls and identified common SNPs at a 15q21.1 locus that were associated with STAAD, with odds ratios of...

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PMID: 21909107
DOI: 10.1038/ng.934
PMCID: PMC3244938

Genes

FBN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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