Article
Relationship between Taq1 A dopamine D2 receptor (DRD2) polymorphism and prolactin response to bromperidol.
American journal of medical genetics - 8 Apr 2001
Mihara K, Suzuki A, Kondo T, Yasui-Furukori N, Ono S, Otani K, Kaneko S, Inoue Y
Abstract excerpt
The dopamine D2 receptor (DRD2) gene has a Taq1 A restriction fragment length polymorphism yielding two alleles, A1 and A2. We have previously shown that female patients with the A1 allele show greater prolactin response to nemonapride, a selective antagonist for D2-like dopamine receptors, in schizophrenic patients. In the present study, the relationship between this polymorphism and prolactin response to...
Topics
- Adult
- Alleles
- Deoxyribonucleases, Type II Site-Specific
- Dopamine Antagonists
- Female
- Genotype
- Haloperidol
- Humans
- Hyperprolactinemia
- Japan
- Male