Article
Control of Amino Acid Homeostasis by a Ubiquitin Ligase-Coactivator Protein Complex.
The Journal of biological chemistry - 3 Mar 2017
Guerra Damian, Chapiro Sonia M, Pratelli Réjane, Yu Shi, Jia Weitao, Leary Julie, Pilot Guillaume, Callis Judy
Abstract excerpt
Intercellular amino acid transport is essential for the growth of all multicellular organisms, and its dysregulation is implicated in developmental disorders. By an unknown mechanism, amino acid efflux is stimulated in plants by overexpression of a membrane-localized protein (GLUTAMINE DUMPER 1 (GDU1)) that requires a ubiquitin ligase (LOSS OF GDU 2 (LOG2). Here we further explore the physiological consequences...
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