Article
Magnitude of HDL cholesterol variation after high-dose atorvastatin is genetically determined at the LDL receptor locus in patients with homozygous familial hypercholesterolemia.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2003
Sposito Andrei C, Gonbert Sophie, Bruckert Eric, Atassi Marielle, Beucler Isabel, Amsellem Sabine, Khallouf Oumayma, Benlian Pascale, Turpin Gerard
Abstract excerpt
OBJECTIVE: The combination of LDL apheresis with high doses of a potent hepatic hydroxymethylglutaryl coenzyme A reductase inhibitor, such as atorvastatin, has been the best therapy available for the prevention of cardiovascular disease in patients with homozygous familial hypercholesterolemia (HFH). However, some concerns have been made about the effect of atorvastatin on HDL cholesterol levels in these...
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