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Article

Requirement of Phospholipase Cδ4 for the Zona Pellucida-Induced Acrosome Reaction

4 May 2001

Abstract excerpt

Several phospholipase C (PLC) isoforms have been found in male and female mammalian gametes, and splicing isoforms of PLCdelta4 are predominantly expressed in testis. Here we report that male mice in which the PLCdelta4 gene had been disrupted either produced few small litters or were sterile. In vitro fertilization studies showed that insemination with PLCdelta4-/- sperm resulted in significantly fewer eggs...

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PMID: 11340203
DOI: 10.1126/science.1059042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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