Article
Diagnosis of concurrent hemoglobin H disease and heterozygous beta-thalassemia.
Haematologica - 1 Apr 2001
Ma E S, Chan A Y, Au W Y, Yeung Y M, Chan L C
Abstract excerpt
Definitive diagnosis of concurrent hemoglobin (Hb) H disease and heterozygous beta-thalassemia cannot be made from Hb analysis alone, but necessitates genotype analysis and family study. Interactions between alpha- and beta-thalassemia must be considered when investigating moderate to severe hypochromic microcytic anemia of uncertain cause in adult patients from areas with a high prevalence of globin gene mutations.
Topics
- Adult
- Anemia, Hypochromic
- DNA Mutational Analysis
- Female
- Globins
- Heterozygote
- Humans
- Male
- Mutation
- Pregnancy
- Pregnancy Complications, Hematologic
- alpha-Thalassemia