Article
Cell-to-cell contact results in a selective translocation of maternal human immunodeficiency virus type 1 quasispecies across a trophoblastic barrier by both transcytosis and infection.
Journal of virology - 1 May 2001
Lagaye S, Derrien M, Menu E, Coïto C, Tresoldi E, Mauclère P, Scarlatti G, Chaouat G, Barré-Sinoussi F, Bomsel M
Abstract excerpt
Mother-to-child transmission can occur in utero, mainly intrapartum and postpartum in case of breastfeeding. In utero transmission is highly restricted and results in selection of viral variant from the mother to the child. We have developed an in vitro system that mimics the interaction between viruses, infected cells present in maternal blood, and the trophoblast, the first barrier protecting the fetus....
Topics
- Cell Communication
- Cell Fusion
- Cell Polarity
- Endocytosis
- Female
- Genetic Variation
- HIV-1
- Humans
- Infectious Disease Transmission, Vertical
- Intercellular Junctions
- Leukocytes, Mononuclear
- Receptors, CCR5
- Receptors, CXCR4