Article
Antigen-presenting cells represent targets for R5 HIV-1 infection in the first trimester pregnancy uterine mucosa.
PloS one - 22 Jun 2009
Marlin Romain, Nugeyre Marie-Thérèse, de Truchis Claire, Berkane Nadia, Gervaise Amélie, Barré-Sinoussi Françoise, Menu Elisabeth
Abstract excerpt
BACKGROUND: During the first trimester of pregnancy, HIV-1 mother-to-child transmission is relatively rare despite the permissivity of placental cells to cell-to-cell HIV-1 infection. The placenta interacts directly with maternal uterine cells (decidual cells) but the physiological role of the decidua in the control of HIV-1 transmission and whether decidua could be a source of infected cells is unknown....
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