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Article

Organotypic models of type III interferon-mediated protection from Zika virus infections at the maternal–fetal interface

7 Aug 2017

Abstract excerpt

Protecting the fetus from the hematogenous spread of viruses requires multifaceted layers of protection and relies heavily on trophoblasts, the fetal-derived cells that comprise the placental barrier. We showed previously that trophoblasts isolated from full-term placentas resist infection by diverse viruses, including Zika virus (ZIKV), and transfer this resistance to nonplacental cells through the activity of...

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PMID: 28784796
DOI: 10.1073/pnas.1707513114

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