Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence

12 Aug 2025

Abstract excerpt

OBJECTIVES: Activation of neutrophils and release of neutrophil extracellular traps (NETs), proteases and reactive oxygen species (ROS) is pathogenic in immune-mediated inflammatory diseases like rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), driving inflammation and damaging host tissues. The aim of this research was to identify small molecule inhibitors of NET production using a highly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Immune cells in cancer
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40802538
DOI: 10.1093/rheumatology/keaf437

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defencePMID 40802538Read ↗

Neutrophil autophagy and NETosis in COVID-19: perspectivesSemantic proximity Read ↗

Rapid High-Throughput Method for Investigating Physiological Regulation of Neutrophil Extracellular Trap FormationSemantic proximity Read ↗

Regulation of neutrophil function by NAMPTSemantic proximity Read ↗

Automated flow cytometric quantification of human neutrophil extracellular traps (NETs)Semantic proximity Read ↗

Rheumatoid arthritis synovial fluid neutrophils drive inflammation through production of chemokines, reactive oxygen species and neutrophil extracellular trapsSemantic proximity Read ↗

NETosis: how vital is it?Semantic proximity Read ↗

Autophagy-mediated regulation of neutrophils and clinical applicationsSemantic proximity Read ↗

Investigating neutrophil cell death in TB pathogenesisSemantic proximity Read ↗

A serpinB1 regulatory mechanism is essential for restricting neutrophil extracellular trap generation.Semantic proximity Read ↗

New Aspects of the Biology of Neutrophil Extracellular TrapsSemantic proximity Read ↗

Defining PANoptosis: Biochemical and Mechanistic Evaluation of Innate Immune Cell Death ActivationSemantic proximity Read ↗

Altered neutrophil G-protein receptor signalling linked to impaired chemotaxis and increased ROS and NET production in older people with frailtySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.