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Article

Cross-utilisation of template RNAs by alphavirus replicases

4 Sept 2020

Abstract excerpt

Most alphaviruses (family Togaviridae) including Sindbis virus (SINV) and other human pathogens, are transmitted by arthropods. The first open reading frame in their positive strand RNA genome encodes for the non-structural polyprotein, a precursor to four separate subunits of the replicase. The replicase interacts with cis-acting elements located near the intergenic region and at the ends of the viral RNA...

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PMID: 32886709
DOI: 10.1371/journal.ppat.1008825

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