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Article

Caveolin-1(-/-)- and caveolin-2(-/-)-deficient mice both display numerous skeletal muscle abnormalities, with tubular aggregate formation.

The American journal of pathology - 1 Jan 2007

Schubert William, Sotgia Federica, Cohen Alex W, Capozza Franco, Bonuccelli Gloria, Bruno Claudio, Minetti Carlo, Bonilla Eduardo, Dimauro Salvatore, Lisanti Michael P

Abstract excerpt

Here, we examine the role of "non-muscle" caveolins (Cav-1 and Cav-2) in skeletal muscle biology. Our results indicate that skeletal muscle fibers from male Cav-1(-/-) and Cav-2(-/-) mice show striking abnormalities, such as tubular aggregates, mitochondrial proliferation/aggregation, and increased numbers of M-cadherin-positive satellite cells. Notably, these skeletal muscle defects were more pronounced with...

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Identifiers

PMID: 17200204
DOI: 10.2353/ajpath.2007.060687
PMCID: PMC1762679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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