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Article

Studies on the biosynthesis of epothilones: the PKS and Epothilone C/D monooxygenase.

The Journal of antibiotics - 1 Feb 2001

Gerth K, Steinmetz H, Höfle G, Reichenbach H

Abstract excerpt

Nonproducer mutants support the assumption that epothilones A and B are synthesized by the same polyketide synthase (PKS). The endproducts of the PKS, epothilones C and D, compete for the active site of a constitutively synthesized monooxygenase which is regulated by product inhibition. The postulated C-13 hydroxy-epothilones as direct precursors of epothilones C and D were not detected.

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Identifiers

PMID: 11302486
DOI: 10.7164/antibiotics.54.144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Studies on the biosynthesis of epothilones: the PKS and Epothilone C/D monooxygenase.PMID 11302486Read ↗

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Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthaseSemantic proximity Read ↗

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Insights into the stereospecificity of ketoreduction in a modular polyketide synthase.Semantic proximity Read ↗

Allosteric regulation of epoxide opening cascades by a pair of epoxide hydrolases in monensin biosynthesis.Semantic proximity Read ↗

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