Article
Expression of CD56 by human papillomavirus E7-specific CD8+ cytotoxic T lymphocytes correlates with increased intracellular perforin expression and enhanced cytotoxicity against HLA-A2-matched cervical tumor cells.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2001
Santin A D, Hermonat P L, Ravaggi A, Bellone S, Roman J J, Jayaprabhu S, Pecorelli S, Parham G P, Cannon M J
Abstract excerpt
Human papillomavirus (HPV) infection represents the most important risk factor for developing cervical cancer. In this study, we examine the potential of full-length E7-pulsed autologous dendritic cells (DCs) to induce antigen-specific CTL responses from the peripheral blood of healthy individuals against HLA-A2-matched HPV-16 and HPV-18-positive tumor target cells in vitro. We show that DCs pulsed with E7...
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