Article
Identification of a naturally processed HLA-A*0201 HPV18 E7 T cell epitope by tumor cell mediated in vitro vaccination.
International journal of cancer - 10 Apr 2003
Kather Angela, Ferrara Alfonso, Nonn Marion, Schinz Manuela, Nieland John, Schneider Achim, Dürst Matthias, Kaufmann Andreas M
Abstract excerpt
Immunotherapy of HPV-associated disease such as cervical cancer is moving from preclinical investigation to clinical trials. The viral oncoproteins E6 and E7 are ideal target antigens because their expression is mandatory in HPV-transformed tumor cells. T cells are the most important effector cells for therapeutic vaccination strategies. Therefore, the identification and characterization of HPV E6 and E7 T cell...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
