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Human Papillomavirus Type 16 E7 Peptide-Directed CD8+T Cells from Patients with Cervical Cancer Are Cross-Reactive with the Coronavirus NS2 Protein

11 Apr 2003

Abstract excerpt

Human papillomavirus type 16 (HPV16) E6 and E7 oncoproteins are required for cellular transformation and represent candidate targets for HPV-specific and major histocompatibility complex class I-restricted CD8(+)-T-cell responses in patients with cervical cancer. Recent evidence suggests that cross-reactivity represents the inherent nature of the T-cell repertoire. We identified HLA-A2 binding HPV16 E7 variant...

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PMID: 12692247
DOI: 10.1128/jvi.77.9.5464-5474.2003

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