Article
Functional and immunological relevance of Anaplasma marginale major surface protein 1a sequence and structural analysis.
PloS one - 1 Jan 2013
Cabezas-Cruz Alejandro, Passos Lygia M F, Lis Katarzyna, Kenneil Rachel, Valdés James J, Ferrolho Joana, Tonk Miray, Pohl Anna E, Grubhoffer Libor, Zweygarth Erich, Shkap Varda, Ribeiro Mucio F B, Estrada-Peña Agustín, Kocan Katherine M, de la Fuente José
Abstract excerpt
Bovine anaplasmosis is caused by cattle infection with the tick-borne bacterium, Anaplasma marginale. The major surface protein 1a (MSP1a) has been used as a genetic marker for identifying A. marginale strains based on N-terminal tandem repeats and a 5'-UTR microsatellite located in the msp1a gene. The MSP1a tandem repeats contain immune relevant elements and functional domains that bind to bovine erythrocytes...
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