Article
Immunogenetics of longevity. Is major histocompatibility complex polymorphism relevant to the control of human longevity? A review of literature data.
Mechanisms of ageing and development - 30 Apr 2001
Caruso C, Candore G, Romano G C, Lio D, Bonafè M, Valensin S, Franceschi C
Abstract excerpt
Literature data suggest that human longevity may be directly correlated with optimal functioning of the immune system. Therefore, it is likely that one of the genetic determinants of longevity resides in those polymorphisms for the immune system genes that regulate immune responses. Accordingly, studies performed on mice have suggested that the Major Histocompatibility Complex (MHC), known to control a variety of...
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