Article
Association of DRB1*04-DQB1*0301 haplotype and lack of association of two polymorphic sites at CTLA-4 gene with Hashimoto's thyroiditis in an Italian population.
Thyroid : official journal of the American Thyroid Association - 1 Feb 2001
Petrone A, Giorgi G, Mesturino C A, Capizzi M, Cascino I, Nistico L, Osborn J, Di Mario U, Buzzetti R
Abstract excerpt
Hashimoto's thyroiditis (HT) is an autoimmune disease resulting from a complex interaction between genetic and environmental factors. The genetic loci conferring susceptibility need to be still defined. The aim of the present study was to determine whether Cytotoxic T-Lymphocyte-Associated Antigen-4 (CTLA-4), HLA DRB1, and DQB1 genes were associated to HT in an Italian population. We evaluated the allele...
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