Article
Antagonistic effects of the staphylococcal enterotoxin a mutant, SEA(F47A/D227A), on psoriasis in the SCID-hu xenogeneic transplantation model.
The Journal of investigative dermatology - 1 Apr 2001
Boehncke W H, Hardt-Weinelt K, Nilsson H, Wolter M, Dohlsten M, Ochsendorf F R, Kaufmann R, Antonsson P
Abstract excerpt
Psoriasis is a T-cell-mediated immune dermatosis probably triggered by bacterial superantigens. This pathomechanism has been experimentally reproduced in a SCID-hu xenogeneic transplantation model. We analyzed the effects of different bacterial superantigens on the induction of psoriasis in this model. Staphylococcal enterotoxin B and exfoliative toxin triggered the onset of psoriasis when administered...
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