Article
Staphylococcal exotoxins and nasal polyposis: analysis of systemic and local responses.
American journal of rhinology - 1 Jan 2000
Tripathi Anju, Kern Robert, Conley David B, Seiberling Kristin, Klemens Julie C, Harris Kathleen E, Suh Lydia, Huang Jie, Grammer Leslie C
Abstract excerpt
BACKGROUND: Staphylococcal exotoxins have been implicated in the pathogenesis of several chronic inflammatory diseases including atopic dermatitis (AD), asthma, and, most recently, chronic rhinosinusitis with nasal polyposis (CRS/NP). In severe AD, these toxins act both as superantigens (SAg), triggering massive T-cell activation, and as conventional allergens, triggering toxin-specific immunoglobulin E (IgE) in...
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