Novel Peptide from Commensal Staphylococcus simulans Blocks Methicillin-Resistant Staphylococcus aureus Quorum Sensing and Protects Host Skin from Damage

Abstract excerpt

in competition with MRSA reduced dermonecrotic and epicutaneous skin injury in murine models. The addition of synthetic AIP-I also effectively reduced MRSA dermonecrosis and epicutaneous skin injury in murine models. These results demonstrate potent anti-MRSA quorum sensing inhibition by a rare human skin commensal and suggest that cross talk between CoNS and MRSA may be important in maintaining healthy skin...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antimicrobial Peptides and Activities
• Share to Antimicrobial Resistance in Staphylococcus
• Share to Bacterial biofilms and quorum sensing