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Article

Effect of polymorphisms in XPD on clinical outcomes of platinum-based chemotherapy for Chinese non-small cell lung cancer patients.

PloS one - 1 Jan 2012

Wu Wenting, Li Huan, Wang Huibo, Zhao Xueying, Gao Zhiqiang, Qiao Rong, Zhang Wei, Qian Ji, Wang Jiucun, Chen Hongyan, Wei Qingyi, Han Baohui, Lu Daru

Abstract excerpt

PURPOSE: Xeroderma pigmentosum group D (XPD) codes for a DNA helicase involved in nucleotide excision repair that removes platinum-induced DNA damage. Genetic polymorphisms of XPD may affect DNA repair capacity and lead to individual differences in the outcome of patients after chemotherapy. This study aims to identify whether XPD polymorphisms affect clinical efficacy among advanced non-small cell lung cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22479369
DOI: 10.1371/journal.pone.0033200
PMCID: PMC3315552

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GCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Effect of polymorphisms in XPD on clinical outcomes of platinum-based chemotherapy for Chinese non-small cell lung cancer patients.PMID 22479369Read ↗

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