Article
T-786C polymorphism of the endothelial nitric oxide synthase gene and neuralgia-inducing cavitational osteonecrosis of the jaws.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics - 1 Apr 2010
Glueck Charles J, McMahon Robert E, Bouquot Jerry E, Khan Naseer A, Wang Ping
Abstract excerpt
OBJECTIVE: We hypothesized that, similar to idiopathic hip osteonecrosis, the T-786C mutation of the endothelial nitric oxide synthase (eNOS) gene affecting nitric oxide (NO) production was associated with neuralgia-inducing cavitational osteonecrosis of the jaws (NICO). DESIGN: In 22 NICO patients, not having taken bisphosphonates, mutations affecting NO production (eNOS T-786C, stromelysin 5A6A) were measured...
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