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Round spermatids from infertile men exhibit decreased protamine-1 and -2 mRNA

1 Apr 2001

Abstract excerpt

During spermiogenesis, histone-to-protamine exchange causes chromatin condensation. Spermatozoa from infertile men are known to exhibit an increased protamine-1 (PRM1) to protamine-2 (PRM2) protein ratio. Since patients undergoing testicular sperm extraction (TESE) followed by intracytoplasmic sperm injection (ICSI) reveal low fertilization rates, whether the outcome of ICSI could be related to the percentage of...

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PMID: 11278223
DOI: 10.1093/humrep/16.4.709

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