Higher LPS-stimulated TNF-alpha mRNA levels in peripheral blood mononuclear cells from non-Hodgkin's lymphoma patients.

doi:10.1016/s0301-472x(00)00672-x

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Article

Higher LPS-stimulated TNF-alpha mRNA levels in peripheral blood mononuclear cells from non-Hodgkin's lymphoma patients.

Experimental hematology - 1 Mar 2001

Baseggio L, Bienvenu J, Charlot C, Picollet J, Felman P, Coiffier B, Salles G

Abstract excerpt

OBJECTIVE: The aim of the present study was to investigate the capacity of normal immune blood cells from non-Hodgkin's lymphoma patients to produce tumor necrosis factor (TNF) after lipopolysaccharide (LPS) stimulation and the influence of the TNF (-308) polymorphism in this production. MATERIALS AND METHODS: A whole peripheral blood cell assay was utilized following LPS stimulation. At selected incubation...

Topics

Adult
Aged
Alleles
DNA, Complementary
Dactinomycin
Gene Expression Regulation, Neoplastic
Genotype
Humans
Leukocytes, Mononuclear
Lipopolysaccharides
Lymphocyte Activation
Lymphoma, Non-Hodgkin
Middle Aged
Neoplasm Proteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Synthesis Inhibitors

Polymerase Chain Reaction

RNA, Messenger

RNA, Neoplasm

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Open in PubMed

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PMID: 11274761
DOI: 10.1016/s0301-472x(00)00672-x

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