Article
[The role of genetic polymorphisms within tumor necrosis factor promoter gene in non-Hodgkin's lymphomas].
Przeglad lekarski - 1 Jan 2005
Juszczyński Przemysław, Kalinka Ewa, Woszczek Grzegorz, Borowiec Maciej, Robak Tadeusz, Kowalski Marek L, Biliński Przemysław, Coiffiers Bertrand, Salles Gilles, Warzocha Krzysztof
Abstract excerpt
Elevated tumor necrosis factor (TNF) and its soluble receptors (p55 and p75) plasma levels in patients with non-Hodgkin's lymphoma (NHL) have been shown to correlate with various adverse prognostic factors and predict poor NHL outcome. In vitro studies demonstrated that TNF expression level could be influenced by TNF-376, -308, -238, -163 promoters' polymorphisms. To explore whether these polymorphisms confer the...
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