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Gender and neurogenin3 influence the pathogenesis of ketosis-prone diabetes.

Diabetes, obesity & metabolism - 1 Sept 2008

Louet J-F, Smith S B, Gautier J-F, Molokhia M, Virally M-L, Kevorkian J-P, Guillausseau P-J, Vexiau P, Charpentier G, German M S, Vaisse C, Urbanek M, Mauvais-Jarvis F

Abstract excerpt

Ketosis-prone diabetes (KPD) is a phenotypically defined form of diabetes characterized by male predominance and severe insulin deficiency. Neurogenin3 (NGN3) is a proendocrine gene, which is essential for the fate of pancreatic beta cells. Mice lacking ngn3 develop early insulin-deficient diabetes. Thus, we hypothesized that gender and variants in NGN3 could predispose to KPD. We have studied clinical and...

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PMID: 18093211
DOI: 10.1111/j.1463-1326.2007.00830.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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