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Article

Design of a Novel Mammalian Screening System for the Detection of Bioavailable, Non-cytotoxic Streptogramin Antibiotics.

1 Jan 2001

Abstract excerpt

Screening and development of new antibiotic activities to counteract the increasing prevalence of multidrug-resistant (MDR) human pathogenic bacteria has once again become a priority in human chemotherapy. Here we describe a novel mammalian cell culture-based screening platform for the detection of streptogramin antibiotics. Quinupristin-dalfopristin (Synercid), a synthetically modified streptogramin, is...

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Identifiers

PMID: 11269714
DOI: 10.7164/antibiotics.54.44

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