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Article

Synergy of Streptogramin Antibiotics Occurs Independently of Their Effects on Translation

24 Jun 2014

Abstract excerpt

Streptogramin antibiotics are divided into types A and B, which in combination can act synergistically. We compared the molecular interactions of the streptogramin combinations Synercid (type A, dalfopristin; type B, quinupristin) and NXL 103 (type A, flopristin; type B, linopristin) with the Escherichia coli 70S ribosome by X-ray crystallography. We further analyzed the activity of the streptogramin components...

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PMID: 24957822
DOI: 10.1128/aac.03389-14

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