Article
[Brugada syndrome].
Nihon rinsho. Japanese journal of clinical medicine - 1 Jul 2002
Matsuo Kiyotaka, Yano Katsusuke
Abstract excerpt
Brugada syndrome is characterized by an ECG pattern of right bundle branch block and ST-segment elevation in right precordial leads, and sudden death caused by ventricular fibrillation(VF). The cellular basis for the syndrome is thought to be due to an outward shift in the ionic current active during phase 1 of the right ventricular epicardial action potential. Mutations of the cardiac sodium channel gene, SCN5A,...
Topics
- Bundle-Branch Block
- Death, Sudden
- Defibrillators, Implantable
- Electrocardiography
- Humans
- Mutation
- NAV1.5 Voltage-Gated Sodium Channel
- Sodium Channels
- Syndrome
- Ventricular Fibrillation