Article
Increased susceptibility of a carrier of X-linked chronic granulomatous disease (CGD) to Aspergillus fumigatus infection associated with age-related skewing of lyonization.
Annals of hematology - 1 Feb 2001
Rösen-Wolff A, Soldan W, Heyne K, Bickhardt J, Gahr M, Roesler J
Abstract excerpt
Chronic granulomatous disease (CGD) is an inherited disorder characterized by the inability of phagocytes to generate normal amounts of superoxide (O2-), leaving patients susceptible to life-threatening infections. It was previously assumed that once carriers of the X-linked form of CGD were found to have 30% or more of functionally normal neutrophils, they would be free of risk for infection because the...
Topics
- Aging
- Aspergillosis
- Aspergillus fumigatus
- Female
- Gene Dosage
- Genetic Linkage
- Genetic Predisposition to Disease
- Granulomatous Disease, Chronic
- Heterozygote
- Humans
- Middle Aged
- X Chromosome