Article
Identification of 2127 new HLA class I alleles in potential stem cell donors from Germany, the United States and Poland.
Tissue antigens - 1 Mar 2014
Hernández-Frederick C J, Giani A S, Cereb N, Sauter J, Silva-González R, Pingel J, Schmidt A H, Ehninger G, Yang S Y
Abstract excerpt
We describe 2127 new human leukocyte antigen (HLA) class I alleles found in registered stem cell donors. These alleles represent 28.9% of the currently known class I alleles. Comparing new allele sequences to homologous sequences, we found 68.1% nonsynonymous nucleotide substitutions, 28.9% silent mutations and 3.0% nonsense mutations. Many substitutions occurred at positions that have not been known to be...
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