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Article

Overexpression of EXTL3/EXTR1 enhances NF-kappaB activity induced by TNF-alpha.

Cellular signalling - 1 Feb 2001

Mizuno K, Irie S, Sato T A

Abstract excerpt

EXTL3/EXTR1 is a member of the EXT gene family, which may represent a class of glycosyltransferases involved in heparan sulfate biosynthesis. It is known that heparan sulfate interacts with a variety of proteins and is therefore implicated in various cellular responses. Here, we examined the effect of EXTL3 on nuclear factor-kappaB (NF-kappaB) activity stimulated by tumor necrosis factor-alpha (TNF-alpha), one of...

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Source

Identifiers

PMID: 11257457
DOI: 10.1016/s0898-6568(00)00144-3

Genes

EXTL3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Overexpression of EXTL3/EXTR1 enhances NF-kappaB activity induced by TNF-alpha.PMID 11257457Read ↗

Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation.Semantic proximity Read ↗

EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner.Semantic proximity Read ↗

Embryonic fibroblasts with a gene trap mutation in Ext1 produce short heparan sulfate chains.Semantic proximity Read ↗

The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate.Semantic proximity Read ↗

Structure of the human heparan sulfate polymerase complex EXT1-EXT2Semantic proximity Read ↗

Mutation in the heparan sulfate biosynthesis enzyme EXT1 influences growth factor signaling and fibroblast interactions with the extracellular matrix.Semantic proximity Read ↗

A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation.Semantic proximity Read ↗

The exostosin family of glycosyltransferases: mRNA expression profiles and heparan sulphate structure in human breast carcinoma cell linesSemantic proximity Read ↗

Identification and Characterization of a Novel Member of the EXT Gene Family, EXTL2Semantic proximity Read ↗

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