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Article

Both cyclooxygenase-1 and cyclooxygenase-2 mediate osteoblast response to titanium surface roughness.

Journal of biomedical materials research - 5 Jun 2001

Boyan B D, Lohmann C H, Sisk M, Liu Y, Sylvia V L, Cochran D L, Dean D D, Schwartz Z

Abstract excerpt

Previous studies suggest that the enhanced expression of the osteoblastic phenotype exhibited by MG63 osteoblast-like cells on rough Ti surfaces (R(a) 4-5 microm) involves increased production of prostaglandin. Inhibition of prostaglandin synthesis by indomethacin blocks surface-roughness-dependent decreases in cell proliferation and increases in alkaline phosphatase activity and the production of osteocalcin and...

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PMID: 11255188
DOI: 10.1002/1097-4636(20010605)55:3<350::aid-jbm1023>3.0.co;2-m

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SLA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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