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Germ cell loss in the XXY male mouse: Altered X-chromosome dosage affects prenatal development

1 Feb 1998

Abstract excerpt

Male mammals with two X chromosomes are sterile due to the demise of virtually all germ cells; however, the underlying reasons for the germ cell loss remain unclear. The use of a breeding scheme for the production of XXY male mice has allowed us to experimentally address the question of when and why germ cells die in the XXY testis and whether the defect is due to the presence of an additional X chromosome in the...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 9444653
DOI: 10.1002/(sici)1098-2795(199802)49:2<101::aid-mrd1>3.0.co;2-t

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