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Article

Point mutations and sequence variability in proteins: redistributions of preexisting populations.

Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2001

Sinha N, Nussinov R

Abstract excerpt

Here we study the effect of point mutations in proteins on the redistributions of the conformational substates. We show that regardless of the location of a mutation in the protein structure and of its type, the observed movements of the backbone recur largely at the same positions in the structu...

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Identifiers

PMID: 11248045
DOI: 10.1073/pnas.051399098
PMCID: PMC30620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11248045-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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