Article
Linking genotype to aorto-coronary atherosclerosis: a model using familial hypercholesterolemia and aorto-coronary calcification.
Annals of human genetics - 1 Nov 1999
Jensen J M, Kruse T A, Brorholt-Petersen J U, Christiansen T M, Jensen H K, Kolvraa S, Faergeman O
Abstract excerpt
Most studies of the pathogenesis of coronary heart disease occur between gene variants and biochemical or physiological variables known to be atherogenic. In many situations, however, the gene products are not necessarily known. We studied 17 families (n = 122) with mutations in the low density lipoprotein (LDL) receptor gene as a model in which to test formally for linkage directly between an atherogenic...
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