Article
Efficient stimulation of T cell responses by human IFN-alpha-induced dendritic cells does not require Toll-like receptor triggering.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jun 2008
Bracci Laura, Schumacher Reto, Provenzano Maurizio, Adamina Michel, Rosenthal Rachel, Groeper Celia, Zajac Paul, Iezzi Giandomenica, Proietti Enrico, Belardelli Filippo, Spagnoli Giulio C
Abstract excerpt
Dendritic cells (DC) can be activated by proinflammatory cytokines or upon toll-like receptor (TLR) triggering. These stimuli induce specific patterns of phenotypic modulation and gene expression profiles. We investigated whether TLR triggering represents an indispensable requirement for the indu...
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