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Article

New insights into the combined Cockayne/xeroderma pigmentosum complex: human XPG protein can function in transcription factor stability.

Molecular cell - 27 Apr 2007

Friedberg Errol C, Wood Richard D

Abstract excerpt

A new study provides evidence supporting a function for XPG protein in maintaining the integrity and function of TFIIH (Ito et al. [2007], this issue of Molecular Cell). This observation likely explains some of the clinical features of individuals with both defective DNA repair and development.

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Share to Cockayne Syndrome
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17466619
DOI: 10.1016/j.molcel.2007.04.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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New insights into the combined Cockayne/xeroderma pigmentosum complex: human XPG protein can function in transcription factor stability.PMID 17466619Read ↗

A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor.Semantic proximity Read ↗

Hot topics in DNA repair: the molecular basis for different disease states caused by mutations in TFIIH and XPG.Semantic proximity Read ↗

Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations.Semantic proximity Read ↗

XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: implications for Cockayne syndrome in XP-G/CS patients.Semantic proximity Read ↗

The Role of TFIIH Complex in Nucleotide Excision RepairSemantic proximity Read ↗

Nucleotide Excision Repair and Transcriptional Regulation: TFIIH and Beyond.Semantic proximity Read ↗

The role of Transcription Factor IIH complex in nucleotide excision repairSemantic proximity Read ↗

Xeroderma pigmentosum and related disorders: defects in DNA repair and transcription.Semantic proximity Read ↗

Role of XPD in cellular functions: To TFIIH and beyond.Semantic proximity Read ↗

ARCH domain of XPD, an anchoring platform for CAK that conditions TFIIH DNA repair and transcription activities.Semantic proximity Read ↗

A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair.Semantic proximity Read ↗

TFIIH: from transcription to clinicSemantic proximity Read ↗

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