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Article

Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes.

The American journal of pathology - 1 Mar 2001

Strathdee G, Appleton K, Illand M, Millan D W, Sargent J, Paul J, Brown R

Abstract excerpt

Mounting evidence suggests that aberrant methylation of CpG islands is a major pathway leading to the inactivation of tumor suppressor genes and the development of cancer. Recent studies on colorectal and gastric cancer have defined a CpG island methylator phenotype (CIMP), which involves the targeting of multiple genes by promoter hypermethylation. To determine the role of methylation in ovarian cancer, we have...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11238060
DOI: 10.1016/S0002-9440(10)64059-X
PMCID: PMC1850352

Genes

BRCA1
HIC1
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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