Article
QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa.
Proceedings of the National Academy of Sciences of the United States of America - 27 Feb 2001
Chugani S A, Whiteley M, Lee K M, D'Argenio D, Manoil C, Greenberg E P
Abstract excerpt
The opportunistic pathogenic bacterium Pseudomonas aeruginosa uses quorum-sensing signaling systems as global regulators of virulence genes. There are two quorum-sensing signal receptor and signal generator pairs, LasR-LasI and RhlR-RhlI. The recently completed P. aeruginosa genome-sequencing project revealed a gene coding for a homolog of the signal receptors, LasR and RhlR. Here we describe a role for this...
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