Article
Vam3p structure reveals conserved and divergent properties of syntaxins.
Nature structural biology - 1 Mar 2001
Dulubova I, Yamaguchi T, Wang Y, Südhof T C, Rizo J
Abstract excerpt
Syntaxins and Sec1/munc18 proteins are central to intracellular membrane fusion. All syntaxins comprise a variable N-terminal region, a conserved SNARE motif that is critical for SNARE complex formation, and a transmembrane region. The N-terminal region of neuronal syntaxin 1A contains a three-helix domain that folds back onto the SNARE motif forming a 'closed' conformation; this conformation is required for...
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