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Article

The prion protein globular domain and disease-related mutants studied by molecular dynamics simulations.

Archives of virology. Supplementum - 1 Jan 2000

Billeter M, Wüthrich K

Abstract excerpt

In humans, familial forms of transmissible spongiform encephalopathies (TSE; "prion diseases") have been shown to segregate with the exchange of individual amino acids in the prion protein (PrP) sequence. We used the NMR structure of the globular domain of mouse PrP in the cellular form (PrP(C)) as a starting point for investigations by long-time molecular dynamics (MD) simulations at ambient temperature of...

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Identifiers

PMID: 11214929
DOI: 10.1007/978-3-7091-6308-5_24

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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