Article
A functional polymorphic variant in the interleukin-6 gene promoter associated with low bone resorption in postmenopausal women.
Arthritis and rheumatism - 1 Jan 2001
Ferrari S L, Garnero P, Emond S, Montgomery H, Humphries S E, Greenspan S L
Abstract excerpt
OBJECTIVE: To examine functional interleukin-6 (IL-6) -174 G-->C allelic variants in relation to bone turnover and bone mineral density (BMD) in postmenopausal women. METHODS: Four hundred thirty-four healthy women living in the community (mean +/- SD age 71.7 +/- 5.7 years) were genotyped for the IL-6 -174 G-->C polymorphism. Serum levels of C-telopeptide of type I collagen (CTx), a marker of bone resorption,...
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