Article
Allele and genotype frequencies of polymorphic cytochromes P4502D6, 2C19 and 2E1 in aborigines from western Australia.
Pharmacogenetics - 1 Feb 2001
Griese E U, Ilett K F, Kitteringham N R, Eichelbaum M, Powell H, Spargo R M, LeSouef P N, Musk A W, Minchin R F
Abstract excerpt
The polymorphisms of the important xenobiotic metabolizing enzymes CYP2D6, CYP2C19 and CYP2E1 have been studied extensively in a large number of populations and show significant heterogeneity in the frequency of different alleles/genotypes and in the prevalence of the extensive and poor metabolizer phenotypes. Understanding of inter-ethnic differences in genotypes is important in prediction of either beneficial...
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