Article
A prospective study of genetic markers of susceptibility to infection and inflammation, and the severity, progression, and regression of coronary atherosclerosis and its response to therapy.
Journal of molecular medicine (Berlin, Germany) - 1 Jan 2000
Elghannam H, Tavackoli S, Ferlic L, Gotto A M, Ballantyne C M, Marian A J
Abstract excerpt
Inflammation plays a key role in susceptibility to coronary atherosclerosis and response to therapy. A diverse array of factors modulates inflammation, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and CD14 receptors on the surface of macrophages. Genes encoding for inflammatory markers have variants that regulate their expression and are potential risk factors for atherosclerosis. We...
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