Article
Protean clinical manifestations in children with leukemias containing MLL-AF10 fusion.
Leukemia - 1 Dec 2000
Gore L, Ess J, Bitter M A, McGavran L, Meltesen L, Wei Q, Hunger S P
Abstract excerpt
Translocations involving the MLL gene on chromosome 11q23 occur in 5-10% of human leukemias, and involve fusion with more than 30 different partner genes. The MLL-AF10 fusion produced by the t(10;11)(p12;q23) or ins(10;11)(p12;q23q13) occurs in a small percentage of acute leukemias, most commonly acute myelogenous leukemia (AML) of the M5 FAB subtype. We report two cases of AML (M5a and M0) and one case of acute...
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