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Article

Birth of two chimeric genes in the Hominidae lineage.

Science (New York, N.Y.) - 16 Feb 2001

Courseaux A, Nahon J L

Abstract excerpt

How genes with newly characterized functions originate remains a fundamental question. PMCHL1 and PMCHL2, two chimeric genes derived from the melanin-concentrating hormone (MCH) gene, offer an opportunity to examine such an issue in the human lineage. Detailed structural, expression, and phylogenetic analysis showed that the PMCHL1 gene was created near 25 million years ago (Ma) by a complex mechanism of exon...

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Identifiers

PMID: 11181993
DOI: 10.1126/science.1057284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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