Article
Evolutionary diversification of DYX1C1 transcripts via an HERV-H LTR integration event.
Genes & genetic systems - 1 Jan 2011
Kim Yun-Ji, Huh Jae-Won, Kim Dae-Soo, Han Kyudong, Kim Hwan-Mook, Kim Heui-Soo
Abstract excerpt
DYX1C1 is a candidate gene for developmental dyslexia and has three alternative pre-mRNA spliced forms in the human genome. One of the transcripts contains an HERV-H LTR that could affect the expression level of DYX1C1. We speculate that the HERV-H LTR integrated into the DYX1C1 locus in the catarrhine lineage after its divergence from the platyrrhine lineage. Reverse transcription-PCR of the HERV-H LTR-related...
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